Associate Principal Scientist / Senior Scientist: Computational Chemistry
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Senior Scientist: Computational Chemistry – 12 months consultant assignment – AstraZeneca
Join a world leading team in developing the next generation of small molecule and PROTACs medicines!
AstraZeneca R&D, Gothenburg, Sweden seeks to recruit into Computational Chemistry, BioPharma Chemistry, Discovery Sciences.
Mission
AstraZeneca is committed to the development of the next generation of innovative medicines. The Computational Chemistry team are using of state of the art in silico methods for molecular modelling, ligand design, property predictions and data analysis as an integral part of BioPharma drug discovery projects with a focus on small to medium sized molecules. The team operates in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Translational, Bioscience, DMPK and Pharmaceutical Sciences departments to advance the BioPharma project pipeline.
Job description
As a Computational Chemist you will have a profound impact on multiple projects across the BioPharma portfolio. You will work collaboratively with medicinal chemists and multidisciplinary teams across all discovery phases. You will efficiently and proactively apply a full range of computational chemistry and AI approaches to deliver design, predictive models and SAR-analysis to improve potency, selectivity, activity and/or ADMET properties of our drug compounds.
You will help identify scientific improvement areas in computational sciences and assess their application to AstraZeneca projects, while contributing to new computational capabilities through collaboration with external partners and colleagues across AZ sites. The role offers opportunities to publish original research and reviews in peer reviewed journals and requires maintaining up to date awareness of the literature and developments in the field.
You’ll work alongside a large community of computational chemists across functions—spanning cheminformatics, molecular simulations, structure‑ and ligand‑based design, machine learning and model development—in a collaborative, cross‑disciplinary environment. You’ll also have access to shared nonperformance compute clusters and postdiphtheritic software to enable co‑folding, FEP/MD, and advanced modelling workflows such as generative design.
Profile
We are seeking an engaged computational chemist with a solid knowledge of drug discovery concepts and a proven track record of applying computational chemistry techniques with measurable impact on drug discovery project delivery. The candidate is expected to have a deep understanding of how computational chemistry contributes to drug discovery projects together with a good knowledge of the drug discovery process including other disciplines, such as synthetic, structural and medicinal chemistry, DMPK, structural biology, biophysics, biological science etc.
Requirements
PhD (or equivalent experience) in the field of computational chemistry or similar. We are seeking an engaged chemoinformatician with a PhD (or equivalent experience) in computational chemistry, chemistry, pharmacology, or a related field with a strong computational background.
Deep knowledge in structure-based drug design techniques, especially molecular dynamics and/or modern FEP methods.
Knowledge in scientific computing, and programming skills (e.g., Python, Perl, C, C++, Java, R).
Strong written and verbal communication skills and ability to collaborate in multidisciplinary project teams
Excellent time management skills, forward planning and delivery focus
Desirable:
Experience in ligand-based design techniques.
Experience in machine learning and cheminformatics
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. The Biopharma unit is one of AstraZeneca´s core therapy areas focused on the discovery and development of novel treatments for cardiovascular, renal, metabolic and respiratory disease into immunology-driven disease areas.
Join a world leading team in developing the next generation of small molecule and PROTACs medicines!
AstraZeneca R&D, Gothenburg, Sweden seeks to recruit into Computational Chemistry, BioPharma Chemistry, Discovery Sciences.
Mission
AstraZeneca is committed to the development of the next generation of innovative medicines. The Computational Chemistry team are using of state of the art in silico methods for molecular modelling, ligand design, property predictions and data analysis as an integral part of BioPharma drug discovery projects with a focus on small to medium sized molecules. The team operates in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Translational, Bioscience, DMPK and Pharmaceutical Sciences departments to advance the BioPharma project pipeline.
Job description
As a Computational Chemist you will have a profound impact on multiple projects across the BioPharma portfolio. You will work collaboratively with medicinal chemists and multidisciplinary teams across all discovery phases. You will efficiently and proactively apply a full range of computational chemistry and AI approaches to deliver design, predictive models and SAR-analysis to improve potency, selectivity, activity and/or ADMET properties of our drug compounds.
You will help identify scientific improvement areas in computational sciences and assess their application to AstraZeneca projects, while contributing to new computational capabilities through collaboration with external partners and colleagues across AZ sites. The role offers opportunities to publish original research and reviews in peer reviewed journals and requires maintaining up to date awareness of the literature and developments in the field.
You’ll work alongside a large community of computational chemists across functions—spanning cheminformatics, molecular simulations, structure‑ and ligand‑based design, machine learning and model development—in a collaborative, cross‑disciplinary environment. You’ll also have access to shared nonperformance compute clusters and postdiphtheritic software to enable co‑folding, FEP/MD, and advanced modelling workflows such as generative design.
Profile
We are seeking an engaged computational chemist with a solid knowledge of drug discovery concepts and a proven track record of applying computational chemistry techniques with measurable impact on drug discovery project delivery. The candidate is expected to have a deep understanding of how computational chemistry contributes to drug discovery projects together with a good knowledge of the drug discovery process including other disciplines, such as synthetic, structural and medicinal chemistry, DMPK, structural biology, biophysics, biological science etc.
Requirements
PhD (or equivalent experience) in the field of computational chemistry or similar. We are seeking an engaged chemoinformatician with a PhD (or equivalent experience) in computational chemistry, chemistry, pharmacology, or a related field with a strong computational background.
Deep knowledge in structure-based drug design techniques, especially molecular dynamics and/or modern FEP methods.
Knowledge in scientific computing, and programming skills (e.g., Python, Perl, C, C++, Java, R).
Strong written and verbal communication skills and ability to collaborate in multidisciplinary project teams
Excellent time management skills, forward planning and delivery focus
Desirable:
Experience in ligand-based design techniques.
Experience in machine learning and cheminformatics
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. The Biopharma unit is one of AstraZeneca´s core therapy areas focused on the discovery and development of novel treatments for cardiovascular, renal, metabolic and respiratory disease into immunology-driven disease areas.